It has been a tumultuous year for the world at large, with COVID-19 necessitating sweeping changes to ways of life across nearly every geography and domain. Against this challenging backdrop, psychedelic medicine has gained a great deal of traction in 2020. Research and development-including clinical trials-has continued to gain momentum and maturity, while public opinion, regulatory bodies, and mainstream media outlets all appear to be increasingly amenable to the prospect of psychedelic medicines and therapies.